Due to the complete absence of plot summaries, character details, or thematic information related to LGBTQ+ representation, an accurate assessment of the film's portrayal of LGBTQ+ characters and themes cannot be made.

There is insufficient information regarding the plot, characters, or themes of 'TOXIC, 2023' to determine if transsexual characters or themes are present or how they might be portrayed. Therefore, an assessment of the film's net impact on the portrayal of transsexual individuals is not possible at this time.

The movie does not contain any action or adventure elements.

There is no information provided regarding source material, prior adaptations, or historical figures for the film "TOXIC, 2023." Without this context, it is impossible to determine if any character portrays a gender different from their established canonical or historical gender.

The film "TOXIC, 2023" is not identified as an adaptation, biopic, or reboot with pre-established characters. Without source material or prior character information, it is impossible to determine if any race swaps occurred according to the definition.