Yo soy Betty, la fea features Hugo Lombardi, a flamboyant fashion designer whose implied gay identity is a significant part of his character. While his portrayal includes some stereotypes and is often played for comedic effect, it is not primarily malicious or degrading. The show integrates his sexuality as a characteristic of a complex individual, neither deeply exploring nor condemning it, leading to a largely neutral net impact.

The series portrays Christianity as an integral part of Colombian culture, with characters frequently referencing God and participating in religious rites. While individual characters may exhibit hypocrisy or moral failings, the narrative consistently upholds virtues like honesty and humility, aligning with the dignity and positive aspects of the faith rather than critiquing the religion itself.