Conclave features Cardinal Benítez, an intersex character who reveals being born with a uterus and ovaries and chose to remain as God made him. The film uses this to explore themes of gender identity, acceptance, and faith, challenging traditional norms within the Church. This progressive inclusion offers a positive and affirming portrayal of an LGBTQ+ issue.

The film features Cardinal Benítez, a character in a historically and canonically male-only role, who is revealed to be intersex. This portrayal introduces a non-binary element to a character in a strictly binary-gendered position, which counts as a gender swap under the provided definition.

Cardinal Benítez, described as Filipino in the source book, is portrayed as Mexican in the film. This constitutes a race swap as Filipino (Asian) and Mexican (often implying Mestizo/Indigenous American) represent distinct racial categories.

The film offers a nuanced portrayal of the Catholic Church, depicting its internal power struggles and corruption alongside genuine spiritual reflection and the potential for renewal. It ultimately affirms the faith's capacity for positive evolution through a leader embodying peace and humility, highlighting its evolving identity.