Mulholland Drive does not feature any identifiable transsexual characters or themes. The narrative focuses on themes of identity, dreams, reality, and the dark side of Hollywood ambition, primarily through the experiences of its cisgender female protagonists.

The movie does not contain any action or adventure elements.

Mulholland Drive is an original film by David Lynch, not an adaptation of pre-existing material with established characters. All characters were created for this specific production, thus there are no instances of a character's gender being changed from a prior canonical or historical depiction.

Mulholland Drive is an original film by David Lynch, not an adaptation of pre-existing material or a historical biopic. All characters were created for this specific production, thus lacking prior canonical or historical racial identities to be altered.