Emilia Pérez features a trans woman whose transition is intertwined with her identity as a violent drug lord. While aiming for a unique perspective, the film draws criticism for potentially reinforcing harmful stereotypes about trans individuals and trivializing gender confirmation surgeries through its narrative and musical elements, leading to a problematic overall portrayal.

"Emilia Pérez" portrays its transsexual protagonist, a former cartel leader, in a widely criticized manner. The film depicts her as manipulative and violent, linking her transition to repentance for past sins, which critics deem problematic. Elements like her voice reverting to a deeper tone reinforce harmful anti-trans stereotypes. Despite a trans actress in the lead, the narrative is largely seen as a cisgender perspective that undermines authentic and positive trans representation, resulting in a net negative impact.

The titular character, Emilia Pérez, established as a Mexican cartel leader, is portrayed by a Spanish actress. Critics describe this casting as "whitewashing" and lacking "phenotypical authenticity" for a character rooted in Mexican identity, indicating a shift in racial portrayal.