Enemy Mine depicts an alien species (Drac) with a unique hermaphroditic biology where individuals can give birth. While this involves a male-presenting character becoming pregnant, it is a species-specific biological trait, not a portrayal of human transsexual identity or themes. The film does not engage with gender identity or social transition.

The movie does not contain any action or adventure elements.

Enemy Mine is an original film and not an adaptation of pre-existing material. All characters, including the Drac species with its unique reproductive biology, were created for this movie. Therefore, no character was previously established as a different gender in prior canon.

The film features a human character and an alien character. The human character's race aligns with the source material. The alien character, being non-human, does not fall under the definition of a race swap, as the concept applies to changes between human racial categories.