Female Trouble does not feature identifiable transsexual characters or themes. While the film is known for its camp aesthetic and gender-bending performances by Divine, the character of Dawn Davenport is portrayed as a cisgender woman, and the narrative focuses on her pursuit of fame and extreme beauty rather than gender identity.

The movie does not contain any action or adventure elements.

Female Trouble is an original film by John Waters, not an adaptation, biopic, or reboot. All characters were created for this film, thus there are no pre-established characters whose gender could be swapped.

Female Trouble is an original film from 1974, not an adaptation of existing material or a biopic. All characters were created for this specific movie, meaning there is no prior canonical or historical race to establish a baseline for any character.