Inside Out 2 does not feature any identifiable LGBTQ+ characters or themes. The narrative focuses on the protagonist's emotional development during adolescence and her relationships with friends, without incorporating queer identities or storylines.

Inside Out 2 does not feature any identifiable transsexual characters or themes. The story centers on the internal emotional landscape of a cisgender teenage girl, Riley, and her personified emotions as she experiences new feelings during adolescence. There are no plot points or character arcs related to transsexual identity.

The film focuses on the personified emotions within a teenage girl's mind. The conflicts and challenges presented are primarily psychological and emotional, not physical. There are no scenes depicting female characters engaging in or winning direct physical combat against male opponents.

Inside Out 2 introduces new emotions, but all returning characters maintain their established genders. The new characters are original to this installment and do not have a prior canonical gender to swap from.

Inside Out 2 introduces new emotions and continues the story with established characters. No previously established character from the original film has been portrayed by an actor of a different race or visually depicted as a different race in this sequel.