The film features Frankie Stein, a main protagonist, who is explicitly non-binary and uses they/them pronouns. This identity is consistently respected and integrated into their character arc of self-discovery and acceptance. The portrayal is affirming, presenting Frankie with dignity and agency, and aligning with the film's broader themes of embracing individuality.

The film features Frankie Stein, a main character who is explicitly non-binary and uses they/them pronouns. Their identity is presented positively, affirmed by peers, and integrated naturally into the narrative without being a source of conflict or negative stereotypes, contributing to an overall affirming message of acceptance.

The character Frankie Stein, originally established as female in the Monster High franchise, is portrayed as non-binary in the 2022 live-action movie, which constitutes a gender swap.

The character Cleo De Nile, who was canonically established as Egyptian in the source material, is portrayed by a white actress in the 2022 movie, constituting a race swap.