Murder Mystery does not feature any identifiable LGBTQ+ characters or themes. The narrative focuses on a heterosexual couple solving a murder mystery, with no elements related to queer identity present in the story.

Murder Mystery (2019) does not feature any identifiable transsexual characters or themes. The film's plot centers on a married couple solving a murder, and transsexual identity is not depicted or referenced in the narrative.

The film features Audrey Spitz, who is involved in a comedic mystery with action elements. While she participates in some chaotic situations and defends herself, there are no instances where she uses skill, strength, or martial arts to achieve victory in direct physical combat against one or more male opponents.

Murder Mystery (2019) is an original film with no pre-existing source material, historical figures, or prior adaptations. All characters were created for this specific movie, meaning there are no established canonical genders to be swapped.

Murder Mystery (2019) is an original film featuring new characters created for the movie. There is no prior source material or historical basis to establish a canonical race for any character, thus precluding the possibility of a race swap.