Prey for the Devil features Father Dante, whose implied homosexuality is depicted as a hidden shame and vulnerability. The demonic antagonist exploits this, using it to torment him and undermine his spiritual strength. This portrayal leans into harmful tropes, presenting queer identity as a source of weakness and sin within a religious context, without offering a counter-narrative or critique.

The film portrays Christianity, specifically Catholicism and its exorcism rituals, as a legitimate and necessary force against genuine demonic evil. While it critiques the Church's patriarchal structures and the psychological toll on its practitioners, the narrative ultimately validates the power of faith and the efficacy of Christian practices in combating supernatural threats.