Scream VI does not feature transsexual characters or themes within its narrative. The film's LGBTQ+ representation is centered on the queer character Mindy Meeks-Martin and her relationship, which is portrayed positively and is central to the plot. However, this representation does not extend to the transsexual community.

The movie does not contain any action or adventure elements.

Scream VI features returning legacy characters Gale Weathers and Kirby Reed, both of whom maintain their established female gender. The new characters introduced, including the individuals behind the Ghostface mask, do not have prior canonical genders to be swapped from.

Scream VI features returning characters portrayed by their original actors, maintaining their established races. All new characters introduced in this installment do not have prior canonical racial depictions to be swapped from.