Dead to Me features Judy Hale's bisexuality and her relationship with Michelle, which is portrayed with dignity and emotional depth. The show normalizes queer relationships, presenting them as integral to the characters' lives without resorting to stereotypes or making identity a source of conflict, resulting in a net positive portrayal.

The show portrays Christian figures like Pastor Wayne as genuinely kind and supportive, and the grief group as a source of community. While a main character expresses cynicism towards religious platitudes, the narrative frames this as her personal struggle with grief rather than a condemnation of the faith itself.

Judaism is depicted through Steve Wood's family and the observance of a shiva, which is shown as a meaningful tradition for grieving and fostering community. While individual characters have flaws, their Jewish identity is presented as a foundational and generally positive aspect of their lives.