The series features Jeremy Darling, a prominent bisexual character whose identity is depicted with complexity and agency. His bisexuality is naturally integrated into his character and relationships, which are treated with the same dramatic significance as heterosexual ones, without being a source of mockery or negative stereotyping. The overall portrayal is affirming.

"Dirty Sexy Money" features Carmelita, a transgender woman, as a significant love interest for Jeremy Darling. While Jeremy initially grapples with her identity, their relationship evolves into one of acceptance and love. The show portrays Carmelita with dignity and complexity, framing Jeremy's initial prejudice as an obstacle he overcomes, thus affirming the worth of transsexual lives and relationships.

The show satirizes the hypocrisy of the wealthy Darling family, who, despite their nominal Christian affiliation, consistently engage in immoral and scandalous behavior. The narrative portrays their religious adherence as a superficial facade, highlighting the disconnect between their public image and private actions without offering significant counterbalancing positive portrayals.