Futurama generally portrays LGBTQ+ themes with a positive, often comedic, lens. The show directly affirms non-traditional relationships through allegories like "robosexual marriage" in "Proposition Infinity." Characters like Bender consistently exhibit pansexuality without narrative condemnation, and the show's satire typically targets societal prejudices rather than the identities themselves, contributing to an overall supportive portrayal.

Futurama features a temporary gender transition for the character Bender in one episode, primarily for comedic effect. While Bender experiences a different identity and relationship, the portrayal avoids strong positive or negative arcs regarding trans identity itself, making its overall impact neutral.

The show features Turanga Leela, who consistently demonstrates superior physical combat skills. She frequently wins hand-to-hand fights against multiple male opponents, including alien guards and various thugs, using martial arts and her natural strength.

Futurama frequently satirizes organized religion, often using 'Robotology' as a direct parody of Christianity. The show highlights perceived dogmatism, hypocrisy, and the potential for harm within religious institutions, positioning the narrative to critique rather than affirm.