Gurren Lagann does not feature any identifiable transsexual characters or themes. The narrative focuses on mecha combat, human evolution, and overcoming impossible odds, without engaging with gender identity in this specific context.

Female characters like Yoko Littner primarily engage in combat using firearms from a distance. Other female characters either do not participate in direct combat or utilize giant mechs (Gunmen) or non-physical abilities for their engagements. No clear instances of female characters defeating male opponents in close-quarters physical combat were identified.

Gurren Lagann is an original anime series, not an adaptation or reboot of pre-existing material. All characters were created for this specific production, thus there is no prior canonical gender to be swapped.

Gurren Lagann is an original anime series from 2007. As the initial source material, there are no prior canonical depictions of its characters' races to compare against, thus no race swaps occurred within this production.