House of the Dragon does not feature any identifiable transsexual characters or themes within its narrative. The series focuses on the Targaryen dynasty's internal conflicts and succession struggles, without incorporating this specific aspect of identity.

The show features powerful female characters, but their influence and actions are primarily political or involve dragon-based warfare. There are no scenes depicting a female character defeating one or more male opponents in direct physical combat using hand-to-hand, martial arts, or melee weapons.

House of the Dragon adapts George R.R. Martin's "Fire & Blood." All major and named characters in the series maintain the same gender as established in the source material. No character canonically, historically, or widely established as one gender is portrayed as a different gender in the show.