First Cow does not feature any identifiable transsexual characters or themes. The story focuses on the bond between two male protagonists and their efforts to make a living in the American frontier, with no narrative elements related to transgender identity or experiences.

The movie does not contain any action or adventure elements.

First Cow is an adaptation of Jonathan Raymond's novel "The Half-Life." The film's main characters, Cookie Figowitz and King-Lu, maintain the same male gender as established in the source material. There are no instances of characters being portrayed as a different gender than their canonical or historical establishment.

First Cow is an adaptation of Jonathan Raymond's novel "The Half-Life." The film's casting of its main characters, including Cookie Figowitz and King-Lu, aligns with their racial descriptions in the source material and the historical context of the Oregon Territory in the 1820s. No established character's race was altered.