Hostiles does not feature any identifiable LGBTQ+ characters or themes. The film's narrative is centered on a Western drama exploring racial tensions and the harsh realities of the frontier, with no elements pertaining to queer identity or experiences.

Hostiles is a Western film set in 1892, centered on themes of war, prejudice, and reconciliation on the American frontier. The narrative does not include any transsexual characters, storylines, or related themes. Therefore, the film has no discernible impact on the portrayal of transsexual identity.

The film features Rosalie Quaid as the primary female character, who is a survivor of violence. While she defends herself and others, her victories are achieved through the use of firearms, not close-quarters physical combat against male opponents. No other female characters engage in or win direct physical combat against men.

Hostiles is an original screenplay featuring characters created specifically for the film. There are no pre-existing canonical or historical characters whose gender could have been altered for this adaptation.

Hostiles is an original story based on a manuscript, not an adaptation of pre-existing material with established character races or a biopic of specific historical figures. All characters are original to the film's narrative, thus no race swaps occurred.