Invincible features a minor but affirming portrayal of LGBTQ+ identity through the character of Bulletproof. His gay relationship is normalized and presented without conflict or negative stereotypes, contributing to a supportive and validating net impact.

The show features Anissa, a powerful Viltrumite, who engages in and wins a brutal close-quarters physical fight against Mark Grayson (Invincible). Her victory is achieved through superior physical strength and combat application.

The character Green Ghost, originally depicted as male in the Invincible comic series, is portrayed as female in the animated show. This constitutes a gender swap for a named, plot-relevant character from the source material.

The animated series "Invincible" features two notable race swaps: Amber Bennett and William Clockwell, who were depicted as white in the original comic series, are portrayed as Black in the show.