Little America features multiple episodes with LGBTQ+ characters, portraying their experiences with dignity, complexity, and empathy. The series highlights external obstacles like prejudice and cultural expectations, but consistently affirms the worth of queer identities and relationships, resulting in a net positive portrayal.

The series portrays Christianity as a source of strength, community, and moral grounding for immigrant characters in episodes like 'The Manager' and 'The Grand Prize Game'. It is depicted as an integral, supportive aspect of their identity and resilience without any negative critique.

The series portrays Muslim characters with dignity, showcasing their faith as a source of cultural connection and resilience, while clearly condemning any prejudice they face.

The series strongly condemns bigotry against Sikh characters, portraying their faith and practices with profound respect and sympathy as they navigate discrimination.