The show features Bunny Washington, a prominent gang leader, who is openly gay. His sexuality is depicted as a matter-of-fact aspect of his complex character, neither central to the plot nor a source of ridicule or affirmation, resulting in a neutral portrayal.

The show portrays Christianity within a corrupt and violent world where its moral principles are largely ineffective or ignored by its nominal adherents. Religious institutions and figures are often depicted as either complicit, hypocritical, or powerless against the pervasive brutality, failing to offer genuine solace or guidance.

Islam is primarily depicted within the prison system as a source of group identity and cohesion among inmates. While offering a form of structure, the portrayal often links it to power dynamics and survival in a brutal environment, without exploring its spiritual depth or offering a counterbalancing positive narrative.