Roswell, New Mexico features prominent and complex LGBTQ+ characters, most notably the bisexual Michael Guerin and gay Alex Manes. Their relationship is a central, affirming love story depicted with dignity and agency, overcoming external challenges. The series consistently portrays queer identities as valid and worthy of love and happiness, resulting in a net positive impact.

The show adapts characters from the 'Roswell High' book series and the 1999 TV show. Key characters like Liz Parker (now Ortecho), Maria DeLuca, and Kyle Valenti, who were originally depicted as white, are portrayed by Latina, Black, and Mexican-American actors, respectively.

While the show critiques the misuse of Christian rhetoric to justify xenophobia against aliens, it consistently portrays individual Christian characters, like Arturo Ortecho, with respect, depicting their faith as a source of moral guidance and strength. The narrative frames bigotry as wrong, aligning with the virtues of the faith rather than condemning it.