'Sex, Explained' offers an educational and inclusive exploration of human sexuality. It covers diverse sexual orientations and gender identities factually and respectfully, contributing to a broader understanding and destigmatization of LGBTQ+ experiences. The series' overall portrayal is affirming and validating.

The series dedicates an episode to gender identity, featuring interviews with transgender individuals who share their experiences. It educates viewers on the distinctions between sex, gender identity, and expression, presenting transsexual identities with dignity and affirming their validity. The portrayal is respectful, empathetic, and aims to foster understanding.

The series critically examines how traditional Christian doctrines have historically shaped Western attitudes towards sex, often promoting restrictive views on premarital sex, homosexuality, and female sexuality. The narrative frames these influences as problematic, contributing to shame and repression, and implicitly advocates for more inclusive and sex-positive perspectives.