Solar Opposites features LGBTQ+ characters, including the gay couple Tim and Pedro in the Wall subplot, whose relationship is portrayed with dignity, complexity, and heroism. Their love story serves as a respected emotional core. Additionally, Aisha identifies as non-binary without negative framing. The show's overall portrayal is affirming, treating queer identities as integral to characters rather than sources of mockery or degradation.

Solar Opposites features Cherie, a trans woman, as a prominent character in 'The Wall' storyline. Her identity is handled with respect, and her relationship with Tim is portrayed as a genuine love story. The show avoids harmful stereotypes, affirming her dignity and agency within the narrative.

The show consistently portrays Christianity through a satirical lens, often highlighting perceived human irrationality, hypocrisy, or the commercialization of its holidays and practices. The narrative frequently positions Christian beliefs and institutions as subjects of alien misunderstanding or human absurdity, without offering significant counterbalancing positive portrayals.