The Adventures of Sam & Max: Freelance Police is a comedic animated series centered on two freelance detectives. The show does not include any discernible LGBTQ+ characters or explore related themes, resulting in no specific portrayal to evaluate.

The animated series "The Adventures of Sam & Max: Freelance Police" does not feature any identifiable transsexual characters or themes. The narrative focuses on the comedic, surreal adventures of its titular characters, with no elements related to transgender identity present in its storylines.

The animated series primarily focuses on the comedic adventures of Sam and Max. Female characters are present but are not depicted in roles that involve direct physical combat. There are no instances where a female character defeats one or more male opponents in close-quarters physical combat.

The animated series "The Adventures of Sam & Max: Freelance Police" faithfully adapts the titular characters, Sam and Max, from the original comic books, retaining their established male genders. No other significant characters from the source material underwent a gender change in this adaptation.

The main characters, Sam and Max, are anthropomorphic animals, and the concept of race does not apply to them. No human characters established in the source material were portrayed by actors of a different race in the 1997 animated series.