The Boondocks frequently depicts homophobic characters and language, primarily through satire. While problematic views are presented, the narrative consistently critiques bigotry by portraying such characters as flawed or villainous, thus neither affirming nor denigrating LGBTQ+ identity directly but rather satirizing societal prejudice.

The show features several female characters, members of the Hateocracy, who are highly skilled martial artists. They engage in and win direct physical combat against multiple male opponents, including Robert Freeman, demonstrating superior fighting ability through skill and strength.

The show frequently satirizes the hypocrisy, commercialization, and abuse of power within Christian institutions and among certain adherents (e.g., televangelists, Uncle Ruckus's hateful 'religion'), with the narrative clearly condemning these problematic aspects.

Through Huey's intellectual curiosity and admiration for figures like Malcolm X, the show subtly associates aspects of Islamic thought with revolutionary ideals, justice, and integrity, positioning these elements in a sympathetic light.