The Legend of Vox Machina does not feature any explicitly identifiable transsexual characters or themes within its narrative. While some characters may have canonical gender identities outside the show's direct portrayal, these are not depicted or explored within the series itself.

The movie does not contain any action or adventure elements.

The animated series is a direct adaptation of the Critical Role Dungeons & Dragons campaign, with all established characters retaining their original genders from the source material.

The animated series faithfully adapts the established visual designs and implied racial characteristics of its characters from the original Critical Role web series. No major or legacy characters are depicted as a different race than their source material counterparts.