The Peripheral features Ash, a prominent lesbian character, whose identity and relationship with another woman are depicted as a natural, integrated part of the futuristic setting. Her sexuality is neither central to the plot nor a source of conflict or stereotype. The portrayal is incidental, presenting queer identity without strong positive or negative thematic emphasis.

The Peripheral features Ash, a non-binary character who is a crucial and intelligent scientist. Their identity is respectfully acknowledged through pronouns but is not central to their character arc or the plot. The portrayal is incidental, neither explicitly affirming nor denigrating, presenting the character with dignity and competence.

Wilf Netherton and Cherise Netherton, characters described with pale skin in William Gibson's source novel, are portrayed by Black actors Gary Carr and T'Nia Miller, respectively, in the series.