The show features Laura, Sarah's lesbian sister, and her long-term girlfriend, Jay. Their relationship is consistently portrayed as stable, loving, and normalized within the show's satirical world. While the show's humor is often edgy, their queer identity is not the primary target of ridicule, and they are depicted with agency and complexity, often serving as a grounded contrast to the protagonist's antics.

The show features transsexual characters in a comedic context. While one episode explores a character dating a trans woman, often highlighting others' discomfort, another episode uses a derogatory slur as a character's name, primarily for offensive comedic effect, contributing to a problematic portrayal.

Christianity is often depicted through Sarah's character's interactions with her Christian neighbors, where her irreverent and often prejudiced views are satirized. The show consistently frames Sarah's character as an unreliable and flawed protagonist, ensuring that her offensive statements about Christian beliefs are presented as absurd and inappropriate, rather than an endorsement of a negative portrayal of the religion.

The show frequently engages with Jewish identity and culture through its protagonist, often using satire to critique antisemitism or societal prejudices rather than the faith itself. While Sarah's character makes provocative jokes, the narrative often highlights the absurdity of her views or the broader societal issues.