The series' central premise revolves around the integration of diverse, often marginalized, populations and a satirical critique of the bureaucratic systems designed to manage them, aligning with progressive values of diversity and social justice. While not explicitly political, its dominant themes consistently explore the challenges of coexistence and the need for empathy in a complex society.

Ugly Americans explores themes of diversity and integration through its allegorical premise of a human social worker assisting various non-human residents. While the show's core concept revolves around the challenges of a diverse society, its casting does not feature explicit racial or gender swaps of traditionally white roles, and its narrative does not explicitly critique traditional identities.