Veronica Mars features LGBTQ+ characters, most notably Mac Mackenzie, whose bisexuality is depicted with dignity and complexity in a healthy relationship. The show's portrayal is affirming, presenting queer identities as normal and respected aspects of its characters' lives, contributing to a net positive impact.

Veronica Mars features a transgender character, Corny, who is a victim of a hate crime. The show's narrative strongly condemns the prejudice and violence she faces, with the protagonist, Veronica, treating her with respect and actively seeking justice. This portrayal frames external prejudice as the problem, affirming the dignity and worth of trans identity.

The show frequently portrays Christian adherents, particularly within the wealthy elite, as hypocritical, judgmental, and morally compromised. While not attacking the faith itself, the narrative consistently exposes the disconnect between their professed values and their actions, with no significant counterbalancing positive portrayals.