The show features multiple LGBTQ+ characters across its seasons, including bisexual, gay, and lesbian individuals. Their identities are explored with complexity, dignity, and empathy, focusing on personal journeys and relationships. While some storylines involve tragedy or societal struggles, these are framed externally, and the overall portrayal affirms the worth of queer lives and love, avoiding harmful stereotypes.

Why Women Kill features Dee Fillmore, a transsexual character depicted with dignity and complexity. Her identity is handled respectfully, with challenges framed as external rather than inherent to her transness. The narrative affirms her worth and capacity for love and acceptance, contributing to a net positive portrayal.