Wu-Tang: An American Saga is a biographical drama series chronicling the formation of the hip-hop group Wu-Tang Clan. The narrative primarily focuses on the lives of its members, their struggles, and their rise in the music industry. There are no identifiable LGBTQ+ characters or themes present within the series' storyline.

Wu-Tang: An American Saga focuses on the formation of the Wu-Tang Clan, depicting their lives, struggles, and rise in the music industry. The narrative does not include identifiable transsexual characters or themes, therefore, there is no portrayal to evaluate within the series.

The movie does not contain any action or adventure elements.

The series portrays the real-life members of the Wu-Tang Clan and other historical figures involved in their story. All depicted characters maintain their historically documented genders, with no instances of a character established as one gender being portrayed as another.

The show portrays real-life members of the Wu-Tang Clan and their associates. All main characters are depicted by actors whose race aligns with the historical figures they represent, thus no race swaps occurred.