Booksmart features a prominent lesbian protagonist whose identity is normalized and affirmed throughout the narrative. Her romantic journey is depicted with dignity and complexity, culminating in a positive and authentic queer relationship within a supportive social context, contributing to an overall affirming portrayal.

Booksmart features George, a non-binary character, whose identity is portrayed positively and without conflict. The film normalizes George's they/them pronouns and depicts a respectful, affirming romantic relationship with a main character, contributing to a supportive representation of transgender identity.