The film "Brüno" presents its central gay character as an extreme caricature, using his flamboyant identity and stereotypical traits as the primary source of shock humor and mockery. While attempting to satirize homophobia by exposing the prejudices of others, the film's depiction of queer identity itself is largely problematic, relying on exaggeration and ridicule rather than affirmation or dignity.

The film satirizes the hypocrisy, homophobia, and judgmental attitudes of certain Christian individuals and institutions, particularly within American evangelical culture. By exposing this bigotry, the narrative implicitly condemns it, positioning the audience to reject such prejudice rather than the faith itself.

The film's primary depiction of Islam is through an extremist group presented as 'terrorists.' While the film's broader satire targets media sensationalism and Brüno's ignorance, the portrayal of this group is unequivocally hateful and violent, without any counterbalancing nuance or distinction from the religion itself, risking the reinforcement of negative stereotypes about Islam.

Judaism is depicted in the context of the Israeli-Palestinian conflict, where the film satirizes the intractable nature of the dispute and the individuals involved, rather than the religion itself. The film does not portray Judaism negatively, and its critique is aimed at the conflict and prejudice, aligning with a positive framing by condemning bigotry.