Cars 2 does not include any discernible LGBTQ+ characters or themes. The narrative focuses on the adventures of anthropomorphic vehicles in a spy-thriller plot, with no elements related to queer identity present in the story.

Cars 2 does not feature any identifiable transsexual characters or themes within its narrative. The film's plot centers on a global spy mission and a World Grand Prix, involving its cast of talking cars, without any elements related to transgender identity or experiences.

The film features Holley Shiftwell, a female spy car who participates in action sequences. Her methods of defeating opponents primarily involve high-speed chases, strategic maneuvers, and the use of various spy gadgets and technology, rather than direct physical combat.

Cars 2 is a sequel where all returning characters maintain their established genders from the original film. New characters introduced in this installment do not have prior canonical genders to swap from.

The characters in "Cars 2" are anthropomorphic vehicles, not humans. The concept of human race does not apply to these characters, making a "race swap" impossible within the film's context.