The film 'Cruella' does not contain identifiable transsexual characters or themes. While it features a gender-nonconforming character, Artie, the narrative does not delve into specific transsexual identity or experiences, focusing instead on their unique style and personality within the story.

The film focuses on strategic and psychological conflict between its female leads, Cruella and the Baroness. Neither character engages in direct physical combat where they defeat one or more male opponents using skill, strength, or martial arts.

The film "Cruella" introduces new characters and reimagines existing ones from the "101 Dalmatians" canon. All characters with established genders from the source material, such as Cruella, Jasper, Horace, Roger, and Anita, maintain their original genders in this adaptation. No character's gender was changed from their prior canonical portrayal.