Drug War is a crime thriller centered on drug enforcement and criminal activities. The narrative does not feature any identifiable LGBTQ+ characters or explore related themes, thus there is no portrayal to evaluate within the film's scope.

The film 'Drug War' does not feature any identifiable transsexual characters or themes. Its narrative is solely dedicated to a police investigation into a drug trafficking ring, with no elements related to transgender identity present in the story.

The film features female characters who participate in the drug operation and the climactic shootout. However, their involvement in combat is primarily through the use of firearms. There are no scenes depicting a female character defeating one or more male opponents in close-quarters physical combat using skill, strength, or martial arts.

Drug War (2012) is an original film with characters created specifically for this production. There is no prior source material, historical figures, or previous installments from which characters' genders could have been altered.

Drug War is an original film with no prior source material, historical figures, or previous installments. All characters were created for this specific production, thus precluding any race swaps.