Monsters, Inc. does not feature any identifiable LGBTQ+ characters or themes. The story centers on the adventures of Sulley and Mike Wazowski in the monster world, with no elements related to queer identity or experiences.

Monsters, Inc. does not feature any identifiable transsexual characters or themes. The story centers on the monster world's energy crisis and the relationship between a monster and a human child, without touching upon gender identity.

The film features female characters such as Boo, Celia Mae, and Roz. While Boo does contribute to the defeat of Randall, her methods involve her unique scream-generating ability and touch, which do not align with the criteria of skill, strength, or martial arts in direct physical combat. No other female characters engage in or win physical combat against male opponents.

Monsters, Inc. is an original animated film with characters created specifically for this production. There is no prior source material or historical record from which characters' genders could have been altered.

Monsters, Inc. is an original animated film with no prior source material or historical figures. Its characters were created for this film, thus there is no established race to be swapped from.