The series features a prominent lesbian couple, Jin Cheng and Auggie Salazar, whose relationship is depicted with dignity, respect, and normalcy. Their queer identity is integrated into the narrative without being a source of conflict or prejudice, serving as a supportive element in their lives amidst global challenges. The portrayal is affirming and validating.

The show adapts the novel's male protagonist, Wang Miao, by distributing his narrative functions among several new characters, including two prominent female leads, Jin Cheng and Auggie Salazar. This reimagining of a core male role with female characters constitutes a gender swap.

The adaptation of "3 Body Problem" features several main characters who were canonically Chinese in the original novels but are portrayed by actors of different races in the series, globalizing the cast beyond the source material's primary setting.