The show portrays LGBTQ+ themes through the tragic lens of Aaron Hernandez, a closeted gay man whose repressed identity fuels inner turmoil and contributes to his downfall. While offering context and empathy for his struggle, the narrative emphasizes the "queer tragedy" trope, focusing on suffering and societal failure rather than affirmation or empowerment.

The show offers a nuanced and empathetic portrayal of transsexual characters in sports, focusing on their lived experiences, identity affirmation, and the significant societal challenges they face. It explores themes of acceptance and equality, framing obstacles as external forces rather than inherent to trans identity.

The series includes a race swap with the casting of Tammy Blanchard, a white actress, as Terri Hernandez, who is historically of Puerto Rican descent. This represents a divergence from the character's established racial/ethnic background.

The show prominently explores Christianity through themes of religious fervor and internal conflict, particularly in an episode titled "Pray the Gay Away." This narrative focus highlights the problematic aspects of reconciling sexuality with Christian beliefs, suggesting a critical stance on certain interpretations or practices within the faith.