Epic Rap Battles of History features historical figures known to be LGBTQ+, like Freddie Mercury and Oscar Wilde. However, their queer identities are not central to their portrayals, nor are they used for mockery or affirmation. The series maintains a neutral stance, focusing on their public achievements and comedic rivalries, resulting in an incidental depiction.

The show frequently features white actors portraying numerous historical figures and established characters who are canonically or historically of different races, such as Martin Luther King Jr. or Gandhi. This constitutes multiple instances of race swapping.

The series frequently features Christian figures whose beliefs, practices, or historical actions are satirically mocked and ridiculed by their opponents for comedic effect. The narrative does not offer counterbalancing positive portrayals or condemn this comedic critique as bigotry.

Jewish figures are often depicted in a satirical manner, with their faith or associated historical events becoming targets for comedic insults from opposing characters. The show's comedic framing highlights perceived flaws or stereotypes without offering narrative nuance or sympathy.