God Friended Me features Ali Finer, a main character's sister, who comes out as bisexual. Her journey of self-discovery and relationships with women are depicted with dignity and family support, contributing to an affirming and positive portrayal of LGBTQ+ identity within the series.

God Friended Me features a trans woman character, Lena, in an episode centered on family reconciliation and acceptance. The portrayal is empathetic, depicting Lena with dignity and addressing challenges as external. The narrative affirms her identity and the importance of understanding, leading to a positive net impact.

The series consistently portrays Christianity, particularly through Reverend Arthur Finer and his church, as a source of community, moral guidance, and compassionate action. While Miles's atheism provides a counterpoint, the narrative ultimately affirms the positive impact of faith in helping individuals and fostering connection.

The series includes Muslim characters whose faith is presented with respect and nuance, showcasing their cultural practices and the positive role Islam plays in their lives and communities. These depictions contribute to the show's message of interfaith understanding and shared human values.

Judaism is depicted through various characters as a respected faith, highlighting its traditions, community values, and the positive influence it has on adherents' lives. The portrayals are consistently respectful and integrate Jewish characters seamlessly into the show's overarching themes of connection and help.