The animated series 'League of Super Evil' focuses on the comedic misadventures of a group of supervillains. There are no discernible LGBTQ+ characters or themes present throughout the show's run, resulting in no portrayal to evaluate.

The animated series 'League of Super Evil' centers on comedic supervillain escapades and does not include any discernible transsexual characters or explore related themes. The narrative remains entirely separate from such portrayals.

The animated series primarily features male characters in combat roles. While female characters like Lightning Liz are present and participate in villainous schemes, their methods of engagement typically involve superpowers or technological gadgets, not direct physical combat or martial arts against male opponents. No instances of female characters defeating male opponents in close-quarters physical combat were identified.

The League of Super Evil is an original animated series, not an adaptation of pre-existing material. All characters were created for this show, meaning there is no prior canonical gender to be swapped from.

League of Super Evil is an original animated series from 2009. There is no prior source material or historical context for its characters that would establish their race differently before this show's creation. Therefore, no race swaps occurred.