Lovecraft Country features Montrose Freeman, a complex gay character whose struggles with identity and societal homophobia are portrayed with significant empathy. The narrative critiques the prejudice he faces, affirming the dignity and worth of his queer identity despite the tragic elements of his story.

The character of Caleb Braithwhite, a male antagonist in the source novel, is portrayed as Christina Braithwhite, a female character, in the series. This constitutes a clear gender swap for a significant character.

The film portrays the Black church and individual faith as crucial sources of community, resilience, and moral strength for characters facing systemic racism and supernatural threats. While characters grapple with their faith, the narrative ultimately affirms its positive role.