The series features a recurring detective character who is gay, depicted in a relationship without significant narrative emphasis. His sexual orientation is presented as a normal, incidental aspect of his identity, neither central to the plot nor a source of conflict or affirmation, resulting in a neutral portrayal.

The TV series "Murder in the First" features a transgender character, Cassidy, as a witness in a murder case. Her identity is acknowledged, and while there is an instance of misgendering, it is corrected within the narrative. The portrayal is incidental, neither strongly affirming nor problematic, as her identity is not central to the plot and is handled with general respect.