The film incorporates LGBTQ-related themes through exaggerated, comedic, and parodic elements, including gender-bending humor and subversion of traditional gender roles. These elements serve the series' raunchy, adult comedy style and visual impact rather than providing authentic or nuanced LGBTQ+ representation. The portrayal is neither affirming nor denigrating.

The series features multiple female characters, including angels Panty and Stocking, and demon sisters Scanty and Kneesocks, who engage in and win close-quarters physical combat against male opponents. Their victories involve hand-to-hand fighting and melee weapon use.

The film portrays Christian-themed elements (angels, Heaven, Hell, church figures) in a highly irreverent, vulgar, and comedic manner. It consistently depicts its angelic protagonists and religious figures as morally questionable, hypocritical, and driven by base desires, using satire to subvert traditional religious piety and reinforce a negative, albeit comedic, view of these archetypes.