Quantico offers a positive portrayal of LGBTQ+ identity, primarily through its bisexual protagonist, Alex Parrish. Her bisexuality is depicted as a natural and accepted part of her character, with her relationships treated with dignity and complexity, contributing to an affirming representation without sensationalism or negative stereotypes.

The series portrays Muslim characters, particularly the Amin sisters, with depth and complexity, often highlighting the prejudice and profiling they face within the FBI and society. The narrative consistently works to humanize these characters, distinguishing between individual extremist actions and the Islamic faith. This approach positions the audience to condemn bigotry and sympathize with the challenges faced by Muslim individuals.