Riverdale features a prominent and diverse cast of LGBTQ+ characters, including central relationships like Cheryl and Toni, and Kevin's journey. Despite the show's dramatic nature, these characters' identities and relationships are consistently portrayed with dignity and affirmation, overcoming external obstacles rather than being defined by their sexuality as a source of misery or ridicule. The net impact is largely supportive and validating.

Riverdale adapts characters from Archie Comics. Reggie Mantle, canonically white, is portrayed by Asian-American actors. Melody Valentine, also canonically white, is portrayed by a Black actress. The Lodge family (Veronica, Hermione, Hiram), originally depicted as white, are portrayed by Latina actors, with their heritage integrated into the show.

The show frequently portrays Christian-affiliated institutions, such as the Sisters of Quiet Mercy, as corrupt, abusive, and hypocritical. Religious imagery and organizations are often used as a facade for sinister activities or as sources of trauma and oppression within the narrative.